Vallo di Nera is rooted in a deep history reaching back to the Naharci peoples of the 4th-2nd century BC who settled in the area of the meandering Nera river valley. Today's village arose in 1217, with homes tucked against the castle's fortress walls amidst churches and small gardens. In 1522-23, the castle of Vallo was destroyed during an unsuccessful uprising against the Duchy of Spoleto, however was rebuilt shortly after its fall.

Situated in the Province of Perugia, in the Umbria region of Italy, Vallo di Nera is nestled in the Nera River Valley, also called the Valnerina, surrounded by picturesque landscapes and rolling hills. The region is rich in traditional agriculture, including sheep herding, olive groves, and other small farms and artisans. Summertime is the driest and warmest season, with August's temperature averaging 72 °F. January is the coolest month, with an average low temperature of 37 °F. The highest precipitation occurs in April, and the driest month is July, which also has the highest number of daily sunshine hours at just over 12.5. The landscape is beautiful year-round through all the seasons.

Recognized as a "Borghi più belli d'Italia", or Most Beautiful Villages of Italy, Vallo di Nera's beauty provides the perfect setting for its many attractions. Various cultural events and festivals are held throughout the year, including religious processions, historical reenactments, and traditional celebrations that provide insight into the rich cultural heritage, local traditions, and ancient customs of the village and its region.